In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 4858-85-9 as follows. Formula: C4H2Cl2N2
A mixture 2,3-dichloropyrazine (50 g, 0.34 mmol) and concentrated aqueous ammonium hydroxide (200 mL) was stirred at 85 C. in a closed pressure vessel for 4 days. The mixture was cooled to 25 C., water (200 mL) was added, and the mixture was filtered. The solid was washed with water (400 mL), then with dichloromethane (400 mL) and dried under vacuum. Compound 100 was isolated as a white solid 32.5 g (73%). 1H NMR (400 MHz, DMSO-d6 delta 7.93 (d, 1H), 7.55 (d, 1H), 6.79 (bs, 2H).
According to the analysis of related databases, 4858-85-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Schering Corporation; US2007/105864; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem