Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 622392-04-5, name is 2-Bromo-5-iodopyrazine, A new synthetic method of this compound is introduced below., Quality Control of 2-Bromo-5-iodopyrazine
To a 250 ml_ flask were added 2-bromo-5-iodopyrazine (2.9 g, 10 mmol, 1 equiv.), di- te/f-butyl-9H-carbazole (3.0 g, 11 mmol, 1.1 equiv.), copper powder (640 mg, 10 mmol, 1 equiv.) and potassium carbonate (4.5 g, 30 mmol, 3 equiv.). The flask was degassed by three cycles of vacuum-nitrogen purging and 50 ml_ of chlorobenzene was injected. The mixture was stirred at 110 C for 10 h under a nitrogen atmosphere. After cooling, water was added to the reaction mixture followed by extraction with DCM (3 c 50 ml_). The combined organic layers were dried with anhydrous magnesium sulfate. The organic solvent was removed under reduced pressure and the crude product was purified by silica gel column chromatography. DCM/Hexane=1/3 was used as eluent to afford Br-Pz-tCz as a faint yellow solid. Yield: 85%. Rf: 0.65 (33% DCM/Hexanes). Mp: 180-182 C. 1H NMR (400 MHz, CDCI3) d (ppm): 8.84 (d, J = 1.4 Hz, 1 H), 8.74 (d, J = 1.4 Hz, 1 H), 8.13 (dd, J = 2.0, 0.6 Hz, 2H), 7.84 (dd, J = 8.8, 0.7 Hz, 2H), 7.54 (dd, J = 8.7, 2.0 Hz, 2H), 1.49 (s, 18H). 13C NMR (101 MHz, CDCI3) d (ppm): 147.97, 145.94, 145.28, 139.30, 137.06, 134.57, 125.10, 124.37, 1 16.46, 1 10.73, 34.85, 31.87. HR-MS (LTQ Orbitrap XL) [M+H]+ Calculated: (Cz^z/NsBr) 436.1383, 438.1363; Found: 436.1380, 438.1359
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS; ZYSMAN-COLMAN, Eli; CHEN, Dongyang; PACHAI GOUNDER, Rajamalli; (104 pag.)WO2019/202342; (2019); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem