Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 56423-63-3, name is 2-Bromopyrazine, A new synthetic method of this compound is introduced below., category: Pyrazines
A mixture of R-tert-butyl 4-(am inomethyl)-3,3-difluoropiperidine-1-carboxylate (200 mg, 0.80mmol), 2-bromopyrazine (140 mg, 0.88 mmol) and DIPEA (0.42 mL, 2.40 mmol ) in NMP (6 mL) was heated with stirring overnight at 130 C. The mixture was allowed to cool to rt, and diluted with ethylacetate. The organic phase was washed with water and brine, dried over Na2SO4 and concentrated under vacuum. The concentrate was purified by column chromatography over silica gel (hexane/ethyl acetate = 1/1) to afford the title compound as a yellow oil (196 mg, 50%). MS (ESI) calcd for C15H22F2N402: 328.2 ; found: 329.2[M+H]. 1H NMR (400 MHz, CDCI3) 6 7.98 (dd, J = 2.8 and 1.2 Hz, 1H), 7.89 (d, J = 1.2 Hz, 1H), 7.81 (d, J = 2.8 Hz, 1H), 4.80-4.70 (m, 1H), 4.45-4.10 (m, 2H), 3.76-3.69 (m, 1H), 3.57-3.49 (m, 1H), 3.04-2.70 (m, 2H), 2.31-2.16 (m, 1H), 1.87-1.79 (m, 1H), 1.63-1.53 (m, 1H),1.47 (s, 9H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; RUGEN HOLDINGS (CAYMAN) LIMITED; SHAPIRO, Gideon; (246 pag.)WO2016/196513; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem