According to the analysis of related databases, 50866-30-3, the application of this compound in the production field has become more and more popular.
In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 50866-30-3 as follows. Safety of 5-Methylpyrazine-2-carbaldehyde
b) 6-{(3S.4S)-4-ethyl-1-f(5-methylpyrazin-2-vnmethyllpyrrolidin-3-yl>-1- (tetrahvdro-2H-pyran-4-yl)-1.5-dihvdro-4H-pyrazolof3.4-dipyrimidin-4-oneTo a solution -3-yl]-1-(tetrahydro-2H- pyran-4-yl)-1H-pyrazolo[3,4-d]pynmidin-4(5H)-one (4.4g) in dimethylformamide (62 mL) was added acetic acid (2 4 ml_), 5- methylpyrazine-2-carbaldehyde (2g) and sodium tnacetoxyborohydnde (5 27g) The reaction mixture stirred for 2h at ambient temperature and was carefully quenched with saturated sodium bicarbonate solution, extracted 3x with methylene chloride, dried with magnesium sulfate, filtered and concentrated Purification via Biotage MPLC chromatography eluting with 1 – 4% methanol/methylene chlonde/0 5 % saturated ammonium hydroxide provided the title compound (3 9g) 400 MHz 1H NMR (CDCI3) delta 8 52-8 48 (m, 1 H), 8 38 (s, 1 H), 8 02 (s, 1 H), 4 81-4 75 (m, 1 H), 4 1 1 -4 01 (m, 3H), 3 79-3 75 (m, 1 H) , 3 60-3 53 (m, 2H), 3 40-3 32 (m, 1 H), 3 10-3 08 (m, 1 H), 2 94 (m, 1 H), 2 63-2 57 (m, 1 H), 2 53 (d, J = 7 5 Hz, 1 H), 2 37-2 18 (m, 4H), 1 90-1 83 (m, 2H), 1 67-1 60 (m, 1 H), 1 54-1 47 (m, 1 H), 0 95-0 92 (m, 3H) MS (M+H m/z 424 2)
According to the analysis of related databases, 50866-30-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; PFIZER INC.; WO2008/139293; (2008); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem