57948-41-1, name is 3-Bromoimidazo[1,2-a]pyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Quality Control of 3-Bromoimidazo[1,2-a]pyrazine
3-Bromoimidazo[1,2-a]pyrazine (610 mg, 3.08 mmol) was dissolved in dry N,N-dimethylformamide(2mL),Trimethylsilylacetylene (0.68 mL, 6.16 mmol) was added under argonAnd N,N-diisopropylethylamine (1 mL, 6.16 mmol),Thereafter, tetrakistriphenylphosphine palladium (356 mg, 10 mol%) and cuprous iodide (117 mg, 20 mmol%) were added.This mixture was heated to 60 C and allowed to react overnight.After the reaction was completed, the mixture was cooled to EtOAc.To this was added tetra-n-butylammonium fluoride trihydrate (1.262 g, 4 mmol), and the mixture was reacted at room temperature for 1 h.After adding water, ethyl acetate extraction, drying the organic phase with anhydrous sodium sulfate, filtering, and evaporation of solvent.The residue was purified by silica gel column chromatography to give a yellow solid,151mg
The synthetic route of 57948-41-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Wan Huixin; Li Chunli; Shi Chen; Liu Haiyan; Li Ping; Shen Jingkang; (50 pag.)CN104341425; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem