Some common heterocyclic compound, 56423-63-3, name is 2-Bromopyrazine, molecular formula is C4H3BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 2-Bromopyrazine
General procedure: A vial was charged with an aqueous solution of sodium carbonate (1.1 mL, 2 M, 2.2 mmol), toluene (7 mL), 6-(dimethylamino)naphthyl-2-boronic acid (23; 215 mg, 1.0 mmol) and halogenated heteroaromatic compound (1.0 mmol). The reaction mixture was purged with argon, sealed and heated overnight at 110 C with stirring. Upon cooling, the product was extracted with EtOAc, the organic phase was washed with an aqueous solution of NaHCO3, dried over anhydrous sodium sulfate, and the solvent was removed under vacuum. The crude product was purified by column chromatography, followed by crystallization.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 56423-63-3, its application will become more common.
Reference:
Article; ?arlah, David; Juranovi?, Amadej; Ko?ar, Boris; Rejc, Luka; Golobi?, Amalija; Petri?, Andrej; Molecules; vol. 21; 3; (2016);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem