Related Products of 23611-75-8, The chemical industry reduces the impact on the environment during synthesis 23611-75-8, name is Methyl 6-chloropyrazine-2-carboxylate, I believe this compound will play a more active role in future production and life.
1.78 g (10.31 mmol) of methyl 6-chloropyrazine-2-carboxylate synthesized by the method described in Non Patent Literature 1 was dissolved in 20 ml of methylene chloride. To this solution, 1.47 g (17.60 mmol) of O-ethylhydroxylammonium chloride was added. Thereafter, 21.5 ml (1.0 M, n-hexane solution, 21.5 mmol) of trimethylaluminum was added dropwise under nitrogen atmosphere and ice cooling, and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, and Celite filtration was carried out. Then it was extracted with chloroform. The organic layer was dried over anhydrous magnesium sulfate, and the inorganic matter was removed by filtration. The filtrate was concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography to obtain 2.08 g (10.31 mmol, yield 100%) of 6-chloro-N-ethoxypyrazine-2-carboxamide.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 6-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; NIPPON SODA COMPANY LIMITED; ITO, SYUICHI; AMANO, TOMOHIRO; IPPOSHI, JUNJI; KOUBORI, SHINYA; (44 pag.)JP2016/30742; (2016); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem