Application of 356783-16-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 356783-16-9, name is 3,6-Dichloropyrazine-2-carbonitrile belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
(a) In 1.1 L of dimethyl sulfoxide was suspended 90.1 g of 3,6-dichloro-2-pyrazinecarbonitrile. After adding 180.5 g of potassium fluoride and 66.8 g of tetra-n-butylammonium bromide, the mixture was stirred at 50-55 C. for 6 hours. The reaction mixture was returned to room temperature and added to a mixture of 1.1 L of ethyl acetate and 2.2 L of water, and the organic layer was separated. Water (1 L) was added to the organic layer, pH was adjusted to 2.5 with 1 mol/L hydrochloric acid, and the organic layer was separated. The organic layer was washed with saturated aqueous solution of sodium chloride and dried on anhydrous magnesium sulfate, and the solvent was removed under reduced pressure. The residue was purified by silica gel chromatography [eluent: n-hexane:ethyl acetate=10:1] to obtain 58.3 g of 3,6-difluoro-2-pyrazinecarbonitrile as a colorless solid product. R (KBr) cm-1: 2250 H-NMR (CDCl3) delta: 8.34(1H,dd,J=1.3, 7.9 Hz)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,6-Dichloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Toyama Chemical Co., Ltd.; US2003/130213; (2003); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem