In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 312736-49-5 as follows. HPLC of Formula: C5H2Cl2N2O2
3,5-dichloropyrazine-2-carboxylic acid (2.68 g, 13.9 mmol) and sodium bicarbonate (1.4 g,16.6 mmol) in DMF (20 mL) at 230C was added iodomethane (5.21 mL, 83 mmol). The reaction mixture was diluted with 10% aquous citric acid solution and extracted with EtOAc. The combined organic layer was washed with water and brine, dried over MgSO4 and concentrated under reduced pressure to give a brown solid (2.83 g, 13.6 mmol, 98% yield); IH NMR (400 MHz, DMSO-c/6) delta ppm 3.95 (s, 3 H) 8.94 (s, 1 H).
According to the analysis of related databases, 312736-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SIGNAL PHARMACEUTICALS, LLC; WO2009/89042; (2009); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem