Synthetic Route of 54608-52-5,Some common heterocyclic compound, 54608-52-5, name is 2-Hydrazinopyrazine, molecular formula is C4H6N4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: (+)-Usnic acid (1 equiv.) and hydrazines/hydrazides (1.1 equiv.) were added in absolute EtOH under nitrogen and the reaction mixture was stirred at 80C for 2h. For the hydrazines/hydrazides hydrochloride salt materials, they (1.1 equiv) were added to absolute ethanol, and an equivalent amount of pyridine (1.1 equiv) was added dropwise thereto and stirred at 80C under nitrogen. After 5min, (+) – usnic acid was added and the reaction mixture was stirred for another 2h. After reaction was complete, the reaction solution was cooled and concentrated under reduced pressure. The residues were quickly purified by silica gel column (PE/EtOAc).
The synthetic route of 54608-52-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Shi, Cun-Jian; Peng, Wan; Zhao, Jin-Hua; Yang, Hua-Li; Qu, Lai-Liang; Wang, Cheng; Kong, Ling-Yi; Wang, Xiao-Bing; European Journal of Medicinal Chemistry; vol. 187; (2020);,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem