Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 109838-85-9, name is (R)-2-Isopropyl-3,6-dimethoxy-2,5-dihydropyrazine, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C9H16N2O2
The chiral auxiliary group (2.12 g, 11.5 mmol) was dissolved in dry THF solution (10 mL) and cooled to -78 o.n-Butyllithium reagent (2.5 M in hexane, 5.5 mL,13.8 mmol) was added dropwise to the reaction system and reacted at -78 °C for 30 minutes.Add the substrate (3.24 g, 12.1 mmol) in dry THF (10 mL).-78 oC reaction for 60 minutes. After the reaction system is quenched with saturated brine,Take it out from the -78 oC environment and naturally rise to room temperature.It was then extracted 3 times with ethyl acetate (30 mL x 3). Combine the organic phase,Backwash twice with saturated brine (50 mL x 2), dry over anhydrous magnesium sulfate.Filter and concentrate. Obtaining crude product by column chromatography for separation and purification(ethyl acetate: n-hexane = 1: 6), the product was obtained as a pale yellow solid.The yield is 3.85 g,Yield 70percent,
According to the analysis of related databases, 109838-85-9, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Wang Lu; (17 pag.)CN109384806; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem