Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 51171-02-9, name is Methyl 3-Bromo-2-pyrazinecarboxylate, A new synthetic method of this compound is introduced below., Safety of Methyl 3-Bromo-2-pyrazinecarboxylate
To a solution of 6.5 g 3-(2-amino-4-chloro-N-methyl-phenylamino)-pyrazine-2-carboxylic acid methyl ester in 100 ml N,N-dimethyl-formamide are added 5.0 g potassium tert. butylate at 0 C. The mixture is stirred at room temperature for 2 hours, poured into ice water and acidified to pH 4 with glacial acetic acid, whereupon the heading compound is precipitated, m.p. 305-307 (recrystallized from methanol). In analogous manner to that described in Example 1, the following compounds of formula I are obtained: The starting materials of formula III for Examples 10-16, 20-23 and 25 are prepared in analogous manner to that described in Example 1, steps (a) to (e). The starting material of formula III for Examples 2 to 5 and 17 may be obtained as follows: 2.2 g of 3-bromo-pyrazine-2-carboxylic acid methyl ester and 2.2 g 1,2-phenylene diamine suspended in 50 ml triethylamine are boiled for 17 hours under reflux. After the mixture has been cooled, water and ethyl acetate are added to precipitate out pyrazino [2,3-b][1,5]benzodiazepin-11(10H)-one, m.p. 298-300.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Sandoz Ltd.; US4337198; (1982); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem