Application of 13134-38-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 13134-38-8, name is 3,6-Dimethylpyrazin-2-amine, This compound has unique chemical properties. The synthetic route is as follows.
To the solution of thus obtained 2-amino-3,6-dimethylpyrazine (4.0 g, 32.5 mmol) in drydichloromethane (150 mL), 6.89 g (29.5 mmol) of O-(diphenylphosphinyl)hydroxylaminewere added at room temperature. The whole was stirred at room temperature for 20 hours. The mixture was concentrated to the constant mass and after addition of isopropanol (50 mL)- toluene (10 mL) mixture concentrated again to remove traces of water. Dry residue was triturated with ethyl ether. Obtained solid was filtered-off and dried under reduced pressure.6.91 g of the title product as a brown solid were obtained (yield 66%). MS-ESI: (mlz) calculated for C6H10N4 [M+H]: 139.09, found 139.1 (pyrazinium cation); calculated for C12H11O2P [M-H]: 217.04, found 217.1 (diphenylphosphinate anion).
The chemical industry reduces the impact on the environment during synthesis 3,6-Dimethylpyrazin-2-amine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CELON PHARMA S.A.; MOSZCZYNSKI-PETKOWSKI, Rafal; BOJARSKI, Lukasz; WIECZOREK, Maciej; MAJER, Jakub; JANOWSKA, Sylwia; MATLOKA, Mikolaj; BORKOWSKA, Malgorzata; STEFANIAK, Filip; LAMPARSKA-PRZYBYSZ, Monika; DUBIEL, Krzysztof; WO2015/177688; (2015); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem