Adding a certain compound to certain chemical reactions, such as: 5049-61-6, name is Pyrazin-2-amine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5049-61-6, Product Details of 5049-61-6
Step 1 : 2-Amino-5-bromopyrazine: To a 0C cooled and stirred solution of 2-aminopyrazine (10 g, 105 mmol, 1.0 eq) in DCM (1000 mL) was added N-bromosuccinimide (16.8 g, 94.6 mmol, 0.9 eq) portion wise and the resulting solution was stirred at the same temperature for 30 min. The reaction mixture was filtered while keeping the filtrate at 0C and cold water (500 mL) was added to the filtrate. The layers were separated and the organic layer was washed with brine (200 mL), dried (Na2S04) and filtered. The filtrate was concentrated under vacuum. The crude product was purified by re-crystallization using DCM and hexane to afford 12 g of the desired product as a pale yellow solid. 1HNMR (400 MHz, CDC13) delta 8.06 (s, 1H), 7.75 (s, 1H), 4.72 (brs, 2H, D20 exchangeable); ESI-MS (m/z) 174, 176 [(MH)+ Br79′”].
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; LUPIN LIMITED; IRLAPATI, Nageswara, Rao; DESHMUKH, Gokul, Keruji; KARCHE, Vijay, Pandurang; JACHAK, Santosh, Madhukar; SINHA, Neelima; PALLE, Venkata, P.; KAMBOJ, Rajender, Kumar; WO2012/56478; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem