Synthetic Route of 937669-80-2,Some common heterocyclic compound, 937669-80-2, name is 3-Bromopyrazine-2-carboxylic acid, molecular formula is C5H3BrN2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A mixture of 6-(4,6-dimethylpyrimidin-2-yl)-3 ,6-diazabicyclo [3.2.1 ]octane 10-2 (150 mg, 0.69 mmol), 3-bromopyrazine-2-carboxylic acid (167 mg, 0.83 mmol), EDC (198 mg, 1.03mmol), HOAt (140 mg, 1.03 mmol), and N,N-diisopropylethylamine (0.36 mL, 2.06 mmol) in acetonitrile (1 mL) was stirred at room temperature for 24 h. The reaction was concentrated in vacuo and the crude residue was purified by silica gel chromatography (0-100% EtOAc/hexanes, 20 mm) to give 48-1 as an oil. MS (ESI) mlz: 403.3 (M+H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Bromopyrazine-2-carboxylic acid, its application will become more common.
Reference:
Patent; MERCK SHARP & DOHME CORP.; KUDUK, Scott, D.; REGER, Thomas, S.; ROECKER, Anthony, J.; (0 pag.)WO2016/85783; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem