Synthetic Route of 1111638-10-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1111638-10-8, name is 3-Chloro-5H-pyrrolo[2,3-b]pyrazine, This compound has unique chemical properties. The synthetic route is as follows.
Step 1. 2-(3-chloro-5H-pyrroloI23″b]pyrazin-5-yl)-N-(2,2,2-trifluoroethyl)acetamideTo a solution of 3~chloro-5H-pyrrolo[2,3-b]pyrazine (50 mg, 0.326 mmol) in DMF (2 mL) at room temperature was slowly added sodium hydride (20.3 mg, 0.508 mmol). The reaction mixture was allowed to stir for 15 minutes. 2-Bromo-N-(2,252-trifluoroethyl)acetamide (88 mg, 0.40 mmol) was then added and the reaction mixture allowed to stir for 1 hour. Ethanol (0.1 mL) was added to the reaction mixture which was then loaded on to a silica cartridge and purified using medium pressure liquid chromatography (0-10%, methanol/dichloromethane) to yield the title compound. LC-MS (ES, m/z): 293.0 [M+H]+. iH-NMR (400Hz, CDCI3 ppm): 8.95 (1H, t, J=6.1Hz), 8.47 (1H, s), 7.91 (1H, d, J=3.6Hz), 6.72 (1H, d, J=3.6Hz), 5.01 (2H, s), 3.93 (2H, m).
The chemical industry reduces the impact on the environment during synthesis 3-Chloro-5H-pyrrolo[2,3-b]pyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CASH, Brandon; FISCHER, Christian; GARCIA, Yudith; JUNG, Joon; KATZ, Jason; KIM, June; RIVKIN, Alexey; SCHELL, Adam; SIU, Tony; WITTER, David; ZHOU, Hua; WO2011/137022; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem