Reference of 939412-86-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 939412-86-9 name is (3-Chloropyrazin-2-yl)methanamine hydrochloride, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
A 30 vial was charged with 8- (methoxycarbonyl) bicyclo [3.2.1] octane-3-carboxylic acid (830 mg, 3.91 mmol) , HATU (1784 mg, 4.69 mmol) , TEA (1.635 mL, 11.73 mmol) and DCM (20 mL) . The mixture was stirred at 30 for 30 minutes. Then (3-chloropyrazin-2-yl) methanamine hydrochloride (845 mg, 4.69 mmol) was added, the resulting mixture was stirred at 30 for 16 hours. The reaction mixture was diluted with EtOAc (50mL) and washed with brine (50mLx3) . The organic layer was evaporated to dryness and the residue was purified via combi flash (EtOAc in petroleum from 0to 50) to give the title compound. 1H NMR (400 MHz, CDCl3) : delta 8.46 (d, J 2.0 Hz, 1H) , 8.32 (brs, 1H) , 6.85 (brs, 1H) , 4.69-4.59 (m, 2H) , 3.72 (s, 3H) , 2.70-2.50 (m, 4H) , 2.05-1.93 (m, 2H) , 1.89-1.77 (m, 2H) , 1.70 (m, 2H) , 1.65-1.56 (m, 2H) ppm.
At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Chloropyrazin-2-yl)methanamine hydrochloride, and friends who are interested can also refer to it.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIU, Jian; KOZLOWSKI, Joseph A.; ANDRESEN, Brain M.; BOGA, Sobhana Babu; GAO, Xiaolei; GUIADEEN, Deodialsingh; CAI, Jiaqiang; LIU, Shilan; WANG, Dahai; WU, Hao; YANG, Chundao; (111 pag.)WO2016/106624; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem