Related Products of 4430-75-5,Some common heterocyclic compound, 4430-75-5, name is Octahydro-2H-pyrido[1,2-a]pyrazine, molecular formula is C8H16N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1-fluoro-2-nitrobenzene (1.2 g, 8.56 mmol), Octahydro-1H-pyrido [1, 2-a] pyrazine (1.0 g, 7.13mmol), N,N-Diisopropylethylamine (1.9 mL, 10.7 mmol) were added to N,N-dimethylformamide (20 mL), and the reaction was heated to 90 C for 4 hours under nitrogen. After the reaction was cooled to room temperature, the reaction solution was diluted with water (80 mL), extracted with dichloromethane (30 mL X 3), the organic phases were combined and washed successively with water (50 mL) and brine (50 mL), dried over anhydrous sodium sulfate, the solvent was distilled off under reduced pressure, the obtained crude product was passed through a silica gel chromatography column (petroleum ether: ethyl acetate (V:V) = 5:1) and further purified to give the title compound (yellow oil, 1.74 g, 93.4%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Octahydro-2H-pyrido[1,2-a]pyrazine, its application will become more common.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Yi Chao; Zhang Yingjun; Duan Zhenfang; Wang Kezhu; (25 pag.)CN108409728; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem