Adding a certain compound to certain chemical reactions, such as: 58139-04-1, name is 2-Iodo-3-methoxypyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 58139-04-1, COA of Formula: C5H5IN2O
Step 1: tert-Butyl (1-(4-((3-methoxypyrazin-2-yl)ethynyl)phenyl)cyclobutyl)carbamate: To a degassed solution of 2-iodo-3-methoxypyrazine (163 mg, 0.69 mmol) intriethylamine (1.5 mL) at 0 C was added Pd(P’Bu3)2 (14.1 mg, 6 mol%), Cul (1.8 mg, 2 mol%) and fert-butyl (1 -(4-ethynylphenyl)cyclobutyl)carbamate (125 mg, 0.46 mmol). The brown suspension was stirred for 6 hours at room temperature before the reaction mixture was suspended in dichloromethane and washed with brine, dried over magnesium sulphate, filtered and concentrated in vacuo. The resulting residue was purified by silica gel chromatography (gradient 0 to 25% EtOAc in hexane) to give the title compound as a white solid (124 mg, 47%). 1H-NMR (500 MHz, CDCI3) delta 8.15 (s, 1 H), 8.04 (s, 1 H), 7.60 (d, 2H), 7.44 (d, 1 H), 5.30 (bs, 1 H), 4.1 1 (s, 3H), 2.51 -2.56 (m, 4H), 2.09-2.14 (m, 1 H), 1.84-1.91 (m, 1 H), 1.37 (bs, 9H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Iodo-3-methoxypyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ALMAC DISCOVERY LIMITED; BELL, Mark, Peter; O’DOWD, Colin, Roderick; ROUNTREE, James, Samuel, Shane; TREVITT, Graham, Peter; HARRISON, Timothy; MCFARLAND, Mary, Melissa; WO2011/55115; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem