Synthetic Route of 22047-25-2, These common heterocyclic compound, 22047-25-2, name is Acetylpyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Acetylpyrazine (1.22 g, 0.01 mol) and isoniazid (1.37 g, 0.01 mol) were dissolved in 20 mLabsolute ethanol, and 2 drops formic acid was added as a catalyst. The mixture was refluxedfor 5 h, and the white precipitate formed was isolated by filtration to give HL (2.17 g, 90%). IR (KBr, cm-1): 3559, 3030, 1662, 1632, 1562, 1473, 1437, 1420, 1355, 1294, 1153, 1130, 1070,1026, 997, 825, 788, 723, 624, 523, 483. 1H NMR (500 Hz, CDCl3, delta): 9.21 (s, 1H), 9.00 (s, 1H),8.81 (d, J = 10 Hz, 2H), 8.53 (d, J = 10 Hz, 2H), 7.73 (d, J = 5 Hz, 2H), 2.45 (s, 3H). Anal. Calcd forC12H11N5O: C, 59.92; H, 4.59; N, 29.03. Found: C, 72.21; H, 4.57; N, 29.16.
The synthetic route of 22047-25-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhao, Shan-Shan; Wang, Peng; Wang, Li-Na; Fu, Lin; Han, Xiao-Meng; Qin, Jie; Qian, Shao-Song; Journal of Coordination Chemistry; vol. 70; 5; (2017); p. 885 – 897;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem