Synthetic Route of 486424-37-7, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 486424-37-7, name is 3-Amino-6-bromopyrazine-2-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
3-amino-6-bromopyrazine-2-carboxylic acid (500 mg, 2.29 mmol), HOBT (464 mg, 3.44 mmol) and EDCI (660 mg, 3.44 mmol) were dissolved in dry DMF (20 mL), and the resulting solution was stirred for 6 hours. Then 3-fluoroaniline (305 mg, 2.75 mmol) and Et3N (0.43 mL) was added to the mixture. After being stirred overnight, the mixture was diluted with water and extracted with EtOAc. The combined organic phases were washed with brine, dried over Na2S04, filtered and evaporated. The crude product was purified by prep-TLC (PE : EtOAc = 6 : 1) to give the pure product of 3-amino-6-bromo-N-(3-fluorophenyl)pyrazine-2- carboxamide (500 mg, yield: 68%). XH-NMR (CDC13, 400 MHz) delta 9.44 (s, 1H), 8.22 (s, 1H), 7.59 (d, J= 11.2 Hz, 1H), 7.24-7.27 (m, 2H), 6.79-6.82 (m, 1H), 3.21 (s, 2H). MS (M+H)+: 311/ 313.
The chemical industry reduces the impact on the environment during synthesis 3-Amino-6-bromopyrazine-2-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyrazine – Wikipedia,
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