Adding a certain compound to certain chemical reactions, such as: 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 69214-33-1, COA of Formula: C6H4ClN3
To a stirred solution of the product from step 5 (51 .3 mg, 0.1 7 mmol) in THF (5 mL) was added NaH (20.4 tug, 0.51 mmol, 6() wt% in oil) at 0 C. The mixture was stirred at 0 C for0.5 hour, then 8chioroin:iidazo[i,2a]pyrazine (78.() mg, 0.51 mmoi) was added. The resulting mixture was stirred at RT for 2 hours arid then quenched with water (2 n:iL), extracted with EtOAc (3 x 5 mL). The combined organic layer was wished with brine, dried over Na2SO4, filtered and concentrated in vacuo, and the residue was purified by PrepHPLC to give title compound (28.6 mg) as colorless oil. LRIVIS mlz (M+H) 420.2 found, 420.2 required.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Doug C.; MENG, Na; LUO, Yunfu; (127 pag.)WO2016/101119; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem