Related Products of 5780-66-5, The chemical industry reduces the impact on the environment during synthesis 5780-66-5, name is Pyrazine-2-carbaldehyde, I believe this compound will play a more active role in future production and life.
The compound (99 mg) obtained in Example 47-3 and the compound (51.0 mg) obtained in Example 84-1 were dissolved in anhydrous methanol (5.0 ml). The solution was added with sodium cyanoborohydride (35.6 mg) and further added with acetic acid (1.0 ml) to adjust the solution to pH 5, followed by stirring for 5 minutes and then stirring at room temperature for 17 hours. After completion of the reaction, methanol was distilled off and the solution was then added with 1 mol/l sodium hydroxide to adjust the solution to pH 11, followed by extraction with chloroform. The organic layer was washed with saturated saline solution and dried with anhydrous magnesium sulfate. After that, the solvent was distilled off. Then, the residue was purified through silica gel column chromatography (chloroform/methanol) and treated with hydrochloric acid, thereby obtaining hydrochloride (16.8 mg) of the subject compound as a white solid. MS(FAB,Pos.):m/z=512[M+H]+1H-NMR(500MHz,DMSO-d6+D2O):delta=0.82(6H,t,J=7.3Hz),1.42(4H,sext.,J=7.3Hz),2.32(4H,t ,J=7.5Hz),3.48(2H,s),3.71(2H,s),3.73(2H,s),3.77(2H,s),6.85(1 H,s),7.11(1H,s),7.27(2H,d,J=8.5Hz),7.56(2H,d,J=8.3Hz),7.67(2 H,J=8.5Hz),7.89(2H,d,J=8.3Hz),8.51(1H,s),8.55(1H,s),8.84(1H, s).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Pyrazine-2-carbaldehyde, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; EP1550657; (2005); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem