The important role of

Reference of 32111-21-0,Some common heterocyclic compound, 32111-21-0, name is 2-Iodopyrazine, molecular formula is C4H3IN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Example 58; N- f 3-[” 1 -(4-Chloro-phenvU-6-oxo-2-( 4-pyrazin-2-yl-phenylV 1.6-dihvdro-purin-9-yll-phenyl – methane sulfonamide; [00193] A solution of N-(3-{l-(4-chloro-phenyl)-6-oxo-2-[4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yl)-phenyl]-l,6-dihydro-purin-9-yl}-phenyl)-methane sulfonamide (preparaed as described in example 26, 0.5 g, 0.809 mmol) in N,N-dimethylformamide (20 mL) is degassed with argon for 0.5 h. Then 2-iodopyrazine (0.25 g, 1.21 tnmol), cesium carbonate (0.527 g, 1.61 mmol), Pd(dppf)2Cl2 (0.059 g, 0.08 mmol) is added and the resulted mixture is degassed with argon for 0.5 h. The reaction mixture is stirred at rt for 18 h. The reaction mixture is poured into water and extracted with ethyl acetate (3 *). The combined organic layer is washed with brine, dried over Na2SO4, concentrated, and purified by column chromatography to afford N-{3-[l-(4-chloro-phenyl)-6-oxo-2-(4-pyrazin-2-yl-phenyl)-l ,6- dihydro-purin-9-yl]-phenyl}-methane sulfonamide. 1H NMR (DMSOd6, 400 MHz) delta 9.25 (s, IH), 8.69 (m, IH), 8.62 (m, 2H), 8.03 (m, 2H), 7.74 (s, IH), 7.46-7.56 (m, 9H), 7.25 (m, IH), 3.05 (s, 3H); LC-MS calculated for C28H20ClN7O3S (M+H4) 570.1, found 569.9.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-Iodopyrazine, its application will become more common.

Reference:
Patent; IRM LLC; WO2007/120454; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem