Reference of 951626-95-2,Some common heterocyclic compound, 951626-95-2, name is Ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate, molecular formula is C9H11N3O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of ethyl 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylate (30 mg, 0.143 mmol) in acetonitrile (1 mL) was added cesium carbonate (93.4 mg, 0.287 mmol) and benzyl bromide (25.6 muL, 0.215 mmol). The reaction mixture was stirred overnight at 70 C. Upon cooling to room temperature, the cesium carbonate was removed by filtration and the solvent evaporated under reduced pressure to afford crude Intermediate 32. LC-MS: (AA) ES+300.
The synthetic route of 951626-95-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2011/251184; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem