Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 22047-25-2, name is Acetylpyrazine, A new synthetic method of this compound is introduced below., Formula: C6H6N2O
HL was prepared similarly to the published results [37], whereasempolying 2-acetylpyrazine instead of 2-acetylpyridine. In detail, amixture of 2-acetylpyrazine (1.22 g, 10 mmol) and isonicotinoylhydrazide (1.37 g, 10 mmol) in methanol (30 ml) were refluxing for4 h. The pale-yellow solid was precipitated, then filtered andwashed three times by methanol. Yield: 1.54 g (64%). Elementalanalysis for HL (C12H11N5O) (%): Calcd: C: 59.74; H: 4.60; N: 29.03;Found: C: 59.68; H: 4.47; N: 29.24. 1H NMR (400 MHz, CDCl3) d: 9.14(1H)/8.80 (2H)/8.52 (2H)/7.71e7.72 (2H) for AreH, 2.44 (3H, s,eCH3). FT-IR (cm1): n(NH) 3039, n(C]O) 1670 n(C]N) 1555. 13CNMR (100 MHz, CDCl3): d 165.1, 150.3, 149.8, 146.6, 143.2, 145.7,144.4, 140.9, 122.8, 25.9.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Xu, Jun; Zhou, Tao; Xu, Zhou-Qing; Gu, Xin-Nan; Wu, Wei-Na; Chen, Hong; Wang, Yuan; Jia, Lei; Zhu, Tao-Feng; Chen, Ru-Hua; Journal of Molecular Structure; vol. 1128; (2017); p. 448 – 454;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem