Reference of 875781-43-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 875781-43-4 name is 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
The compound prepared in Example 1 (1.26 mg, 0.3 mm), 5-bromo-1 H-pyrrolo [2,3-b] pyrazine (5 9 (63 mg ‘0.006m m o 1), C u I (1 8 mg, 0.09 mm omicron 1), m m L Epsilon13 Nu and 5 m LD Mu F The reaction was stirred at 80 C for 8 hours under inert atmosphere. The end of the reaction was extracted with ethyl acetate and water. The combined organic layers were washed with a saturated NaC1 solution and dried over anhydrous N ^ SOi. Concentrated under reduced pressure, and the residue was purified on a silica gel column to give the compound as an off-white solid. & Lt; 1 & gt; H NMR (500 MHz, CDC13) delta: 8_91 Page 27 of 53
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Bromo-5H-pyrrolo[2,3-b]pyrazine, and friends who are interested can also refer to it.
Reference:
Patent; NANJING SHENGHE PHARMACEUTICAL CO., LTD.; WANG, YONG; ZHAO, LIWEN; LIU, YANG; ZHANG, JINGZHONG; WANG, DEZHONG; GAO, YIPING; CHEN, HONGYAN; ZHANG, CANG; ZHANG, DI; (68 pag.)TWI523856; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem