Application of 24241-18-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 24241-18-7 name is 2-Amino-3,5-dibromopyrazine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
[00195] Step 1 : (Trimethylsilyl)acetylene (1.9 g, 2.7 niL, 18.8 mmol) was added dropwise to a solution of 3,5-dibromopyrazin-2-amine (5.0 g, 19.8 mmol), triethylamine (10.0 g, 13.8 mL, 98.9 mmol), copper (I) iodide (452 mg, 2.37 mmol) and Pd(PPh3)4 (1.14 g, 0.99 mmol) in DMF (25 mL) and the resulting solution stirred at room temperature for 30 min. The reaction was diluted with ethyl acetate and water and the layers separated. The aqueous layer was extracted further with ethyl acetate and the combined organics washed with water, dried over MgS04, and concentrated in vacuo. The mixture was purified via silica gelchromatography (0-15% ethyl acetate/hexanes) to afford 5-bromo-3-((trimethylsilyl) ethynyl)pyrazin-2-amine as a yellow solid (3.99g, 75% yield). ¾ NMR (400 MHz, DMSO- d6) delta 0.30 (s, 9H), 8.06 (s, 1H); MS (ES+) 271.82
At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-Amino-3,5-dibromopyrazine, and friends who are interested can also refer to it.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; CHARRIER, Jean-Damien; BINCH, Haley, Marie; HURLEY, Dennis, James; CLEVELAND, Thomas; JOSHI, Pramod; FANNING, Lev Tyler, Dewey; PINDER, Joanne; O’DONNELL, Michael; VIRANI, Anisa, Nizarali; KNEGTEL, Ronald, Marcellus Alphonsus; DURRANT, Steven, John; YOUNG, Stephen, Clinton; PIERRE-HENRI; KAY, David; REAPER, Philip, Michael; WO2011/143426; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem