Adding a certain compound to certain chemical reactions, such as: 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-75-4, COA of Formula: C5H2ClN3
To a microwave vial was added (2S,3R,4R)-ethyl 1-acetyl-4-amino-2,3-dimethyl-1,2,3,4-tetrahydroquinoline-6-carboxylate (for a preparation see Intermediate 4, 200 mg, 0.689 mmol) and 5-chloropyrazine-2-carbonitrile (192 mg, 1.378 mmol). DMSO (1 mL) was added, followed by DIPEA (0.361 mL, 2.066 mmol) and the microwave vial sealed and heated to 160 C for 30 min in a microwave reactor. H20 (20 mL) was added, followed by Et20 (20 mL) and the layers separated. The aqueous layer was further extracted with Et20 (2 x 20 mL) and the combined organics then back extracted with brine (2 x 20 mL). The combined organics were then dried (Na2S04) and concentrated in vacuo to afford a brown oil. This was loaded in DCM and purified by column chromatography (25 g silica) using a gradient of 0-60% EtOAc / cyclohexane. The appropriate fractions were collected and concentrated in vacuo to afford the product as a brown oil (268 mg). LCMS (2 min Formic): Rt = 1.01 min, [MH]+ = 394.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Chloropyrazine-2-carbonitrile, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.2) LIMITED; ATKINSON, Stephen, John; HIRST, David, Jonathan; HUMPHREYS, Philip, G.; LINDON, Matthew, J.; PRESTON, Alexander, G.; SEAL, Jonathan, Thomas; WELLAWAY, Christopher, Roland; (66 pag.)WO2016/38120; (2016); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem