In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4430-75-5, name is Octahydro-2H-pyrido[1,2-a]pyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. Safety of Octahydro-2H-pyrido[1,2-a]pyrazine
1-fluoro-2-nitrobenzene (1.2 g, 8.56 mmol),Octahydro-1H-pyrido[1,2-a]pyrazine (1.0 g, 7.13 mmol), N,N-diisopropylethylamine (1.9 mL, 10.7 mmol) was added to N,N-dimethyl In formamide (20 mL),The reaction was heated to 90 C under nitrogen for 4 hours.After completion of the reaction, the mixture was cooled to room temperature, and the reaction mixture was diluted with water (80 mL)The organic phases were combined and washed successively with water (50 mL) and brine (50 mL).Dry over anhydrous sodium sulfate, and distill off the solvent under reduced pressure.The resulting crude product was purified by silica gel column chromatography (petroleum ether: ethyl acetate (V: V) = 5: 1) to give further title compound (yellow oil, 1.74g, 93.4%).
The synthetic route of 4430-75-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Jin Chuanfei; Du Changfeng; Zhang Yingjun; (29 pag.)CN108409729; (2018); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem