Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63744-22-9, name is 6,8-Dibromoimidazo[1,2-a]pyrazine, A new synthetic method of this compound is introduced below., Product Details of 63744-22-9
A mixture of known compound 6 (4.0g, 14.44mmol) (25mL), cyclopropylamine (1.5mL, 21.67mmol) and N, N-diisopropylethylamine (3.8mL, 21.67mL) in 1,4-dioxane was stirred at 80C for 5h. The reaction mixture was cooled to room temperature, diluted with ethyl acetate and washed with saturated aqueous NaHCO3. The organic phase was dried over anhydrous Na2SO4 and filtered. The filtrate was concentrated in vacuo. The residue was purified by column chromatography (Hexanes: EtOAc=1:1) to afford the title compound 8 (3.43g, 94%). 1H NMR (300MHz, DMSO-d6) delta 8.08 (s, 1H), 8.02 (s, 1H), 7.80 (s, 1H), 7.46 (s, 1H), 2.88 (m, 1H), 0.67 (m, 4H).
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Article; Kang, Seok Jong; Lee, Jung Wuk; Chung, Shin Hyuck; Jang, Sun Young; Choi, Jaeyul; Suh, Kwee Hyun; Kim, Young Hoon; Ham, Young Jin; Min, Kyung Hoon; European Journal of Medicinal Chemistry; vol. 163; (2019); p. 660 – 670;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem