In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 5521-55-1
A solution of compound A3-1 (30 g, 216 mmol), Boc20 (56.2 g, 260 mmol) and DMAP (7.9 g, 640 mmol) in t-BuOH (800 mL) was stirred at 60 C for 18 h. The solution was concentrated and purified by column (PE: EA = 3: 1) to afford compound A3-2 (40 g, 95%>). 1H NMR (400 MHz, CDC13): 9.05 (d, J= 1.2 Hz, 1H), 8.52 (d, J= 0.8 Hz, 1H), 2.60 (s, 3H), 1.60 (s, 9H).
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; MERCK SHARP & DOHME CORP.; CUMMING, Jared, N.; GILBERT, Eric, J.; STAMFORD, Andrew, W.; WO2012/138734; (2012); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem