Reference of 274-79-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 274-79-3 as follows.
Imidazo[1,2-a]pyrazine (420 mg, 3.53 mmol) was dissolved in acetonitrile (10 mL).N-bromosuccinimide (691 mg, 3.88 mmol) was added thereto, and the mixture was reacted at room temperature overnight.After the reaction is completed, a saturated sodium hydrogencarbonate solution is added thereto.Extract with dichloromethane, dry the organic phase with anhydrous sodium sulfate, filter, and then dry the solvent.The residue was purified by silica gel column chromatography to give a yellow solid,619mg.
According to the analysis of related databases, 274-79-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Shanghai Pharmaceutical Group Co., Ltd.; Wan Huixin; Li Chunli; Shi Chen; Liu Haiyan; Li Ping; Shen Jingkang; (50 pag.)CN104341425; (2018); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem