Electric Literature of 41110-34-3, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 41110-34-3, name is Ethyl 5-methylpyrazine-2-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.
Preparative Example 1 5.40 g of ethyl 5-methylpyrazine-2-carboxylate was dissolved in 54.0 mL of carbon tetrachloride, and 5.78 g of 1-bromosuccinimide and 267 mg of 2,2′-azobis(isobutyronitrile) were added thereto, followed by heating with reflux for 3 hours. The reaction liquid was left to be cooled to room temperature and then concentrated under reduced pressure, and the obtained residue was suspended in 100 mL of ethyl acetate and the insoluble materials were separated by filtration. The filtrate was washed with a saturated aqueous sodium hydrogen carbonate solution, water, and saturated brine, and then dried over anhydrous magnesium sulfate. The solvent was evaporated and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1 to 1:1) to obtain 2.62 g of ethyl 5-(bromomethyl)pyrazine-2-carboxylate.
The chemical industry reduces the impact on the environment during synthesis Ethyl 5-methylpyrazine-2-carboxylate. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Astellas Pharma Inc.; EP2305641; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem