Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 160252-31-3, name is 1-(5-Chloropyrazin-2-yl)ethanone, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C6H5ClN2O
A mixture of (4-(3-(cyclopropylmethoxy)phenoxy)-2-fluorophenyl)methanol (200 mg), 1-(5-chloropyrazin-2-yl)ethanone (119 mg), sodium hydride (60% in oil, 41.6 mg) and THF (1 ml) was stirred at room temperature for 10 min, and heated under microwave irradiation at 100C for 1 hr. To the mixture was added water at 0C, and the mixture was extracted with ethyl acetate. The organic layer was separated, washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (65 mg). 1H NMR (300 MHz, CDCl3) delta 0.27-0.39 (2H, m), 0.60-0.69 (2H, m), 1.19-1.31 (1H, m), 2.66 (3H, s), 3.77 (2H, d, J = 6.9 Hz), 5.48 (2H, s), 6.57-6.65 (2H, m), 6.68-6.86 (3H, m), 7.19-7.29 (1H, m), 7.43 (1H, t, J = 8.4 Hz), 8.23 (1H, d, J = 1.2 Hz), 8.83 (1H, d, J = 1.3 Hz).
According to the analysis of related databases, 160252-31-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Takeda Pharmaceutical Company Limited; MIZOJIRI, Ryo; ASANO, Moriteru; TOMITA, Daisuke; BANNO, Hiroshi; TAWADA, Michiko; NII, Noriyuki; GIPSON, Krista E.; MAEZAKI, Hironobu; TSUCHIYA, Shuntaro; IMAI, Mayumi; AMANO, Yuichiro; (100 pag.)EP3279183; (2018); A1;,
Pyrazine – Wikipedia,
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