Electric Literature of 33332-25-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 33332-25-1, name is Methyl 5-chloropyrazine-2-carboxylate belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
1.4.1 Intermediate 12(S)-Methyl 5-(3-methoxypyrrolidin- l -yl)pyrazine-2-carboxylate To a solution of methyl 5-chloropyrazine-2-carboxylate ( 1 g, 5.8 mmol) in dry acetonitriie (7.2 mL) was added (S)-3-methoxypyrrolidine hydrochloride ( 1 g, 7.5 mmol) and diisopropylethylamine (3 mL, 17.4 mmol). The reaction vial was sealed and heated under microwave conditions at 140 C for 30 minutes. The reaction mixture was partitioned between EtOAc (50 mL) and sodium carbonate (sat soln.) (50 mL). The organics were further extracted with EtOAc (50 mL). The combined organics were washed with water (2 x 50 mL), brine (50 mL), dried over MgS04, filtered and concentrated to give a pale brown oil which crystallised. The crude solid was purified using chromatography on silica using 0- 10% methanol in EtOAc to give (S)-methyl 5-(3-methoxypyrrolidin-l-yl)pyrazine-2-carboxylate (l .lg, 75%). NMR (400 MHz, DMSO-d6) delta 8.66 (s, 1H), 8.05 (s, 1H), 4.06 – 4.18 (m, 1H), 3.81 (s, 3H), 3.55 – 3.73 (m, 3H), 3.43 – 3.54 (m, 1H), 3.28 (s, 3H), 1.98 – 2.20 (m, 2H). MS ES+ 238
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 5-chloropyrazine-2-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; POONI, Parminder, Kaur; MERCHANT, Kevin, John; MAINE, Stephanie, Anne; FIELDHOUSE, Charlotte; SHOWELL, Graham, Andrew; WO2011/83315; (2011); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem