Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5521-55-1, name is 5-Methylpyrazine-2-carboxylic acid, A new synthetic method of this compound is introduced below., COA of Formula: C6H6N2O2
Example 348 W-{[1 -Ethyl-4-(tetrahydro-2H-pyran-4-ylamino)-6-(trif luoromethyl)-1 H- pyrazolo[3,4-Jb]pyridin-5-yl]methyl}-5-methyI-2-pyrazinecarboxamide5-Methyl-2-pyrazinecarboxylic acid (152mg, 1.1mmol, commercially available from e.g. Avocado) was suspended in dichloromethane (3ml) and treated at 200C under nitrogen with oxalyl chloride (0.288ml, 3.3mmol) and diethylformamide (1drop). A vigorous reaction occurred. After 30min the reaction mixture was evaporated to dryness to give a dark yellow oil which was presumed to be 5-methyl-2-pyrazinecarbonyl chloride.A solution of 5-methyl-2-pyrazinecarbonyl chloride (1.1mmol) in dichloromethane (2ml) was added under nitrogen at 2O0C to a stirred mixture of Intermediate 36 (0.343g, 1.Ommol) and diisopropylethylamine (0.77ml, 4.4mmol) in chloroform (7ml). The resulting solution was stirred at 200C under nitrogen for 1.5h. The reaction mixture was evaporated to dryness and the residual oil was dissolved methanol (5ml) and applied to an aminopropyl SPE cartridge (2Og). The cartridge was eluted with methanol (3 column volumes). The product-containing fraction was evaporated to give the crude product as a brown foam (0.403g). This foam was dissolved in dichloromethane (10ml) and applied to a silica SPE cartridge (2Og). The cartridge was eluted using initially a gradient of 0 to 100% ethyl acetate in cyclohexane followed by a gradient of 0 to 20% methanol in ethyl acetate/dichloromethane. The product-containing fraction was evaporated to give Example 348 as a fluorescent yellow solid (0.215g). LCMS showed MH+ = 464; TREtau = 3.23min.
The synthetic route of 5521-55-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; GLAXO GROUP LIMITED; WO2007/36733; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem