55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 55557-52-3
EXAMPLE 5.1 (+-)-3-[(6R,8aS)-6-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]pyrazine-2-carbonitrile (+-)-(6R,8aS)-6-[2-(3-chlorophenyl)-2H-tetrazol-5-yl]octahydropyrrolo[1,2-a]pyrazine (40 mg, 0.131 mmol) was mixed with 3-chloropyrazine-2-carbonitrile (23.8 mg, 0.17 mmol) and Et3N (0.1 mL) in THF (1 mL) in a sealed vial and heated at 90 C. for 30 min. The reaction mixture was quenched with water and extracted with DCM. The product was purified by column chromatography with 20% ethyl acetate in hexanes to give the title compound (23.8 mg, 44.5%, yellow foam). 1H NMR (CDCl3), delta (ppm): 8.27 (s, 1H), 8.26 (s, 1H), 8.08 (d, 1H), 8.03 (s, 1H), 7.49 (m, 2H), 4.69 (d, 1H), 4.52 (d, 1H), 3.86 (t, 1H), 3.30 (d, 1H), 3.22 (d, 1H), 3.11 (dd, 1H), 2.32-2.60 (m, 4H), 2.04 (m, 1H), 1.84 (m, 1H).
The synthetic route of 55557-52-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AstraZeneca AB; NPS Pharmaceuticals; US2007/37816; (2007); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem