Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 69214-33-1, name is 8-Chloroimidazo[1,2-a]pyrazine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 8-Chloroimidazo[1,2-a]pyrazine
?/-(3-(Trifluoromethyl)phenyl)imidazor 1 ‘,2′-alpyrazin-8’-amine (Compound 175) [00238] 3-(Trifluoromethyl)aniline (525 mg, 3.256 mmol) was added to a suspension of sodium hydride (130 mg, 3.256 mmol – 60% in mineral oil) in DMSO (2 mL) and the resulting mixture was stirred under nitrogen atmosphere for 15 minutes. A solution of 8- chloroimidazo[l,2-a]pyrazine (250 mg, 1.628 mmol) in DMSO (2 mL) was then added and stirring continued for another 2 hours. The reaction mixture was then quenched with NH4Cl (sat. aq.) and the product extracted into EtOAc. The organic layer was dried, concentrated in vacuo and purified by flash column chromatography (gradient 2:1 to 3:2 EtOAc:40-60 petrol) to give the title compound (285 mg, 63%). LCMS RT = 6.48 min, MH+ 279. 1H NMR (d6- DMSO): 9.99 (IH, br s), 8.61 (IH, s), 8.32 (IH, d, J 8.8), 8.07 (IH, d, J4.4), 8.04 (IH, d, J 1.1), 7.67 (IH, d, J 1.1), 7.54 (IH, t, J8.2), 7.47 (IH, d, J4.7), 7.32 (IH, d, J7.8).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 69214-33-1.
Reference:
Patent; BioMarin IGA, Ltd.; WREN, Stephen Paul; WYNNE, Graham Michael; LECCI, Cristina; WILSON, Francis Xavier; PRICE, Paul Damien; MIDDLETON, Penny; WO2010/69684; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem