Reference of 91476-80-1, These common heterocyclic compound, 91476-80-1, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(1855) [00533] To a solution of 2-(4-bromophenethyl)isoindoline-l,3-dione (prepared according to the procedure described in Francis et al : Journal of Medicinal Chemistry (1991), 34(8), 2570- 2579; 0.2 M in anhydrous 1,4-dioxane; 150 muEpsilon, 30 mumol), was added 5,6,7,8- tetrah droimidazo[ 1 ,2- Jpyrazine (0,2 M in anhydrous 1 ,4-dioxane; 180 muTau, 36 muetaiotaomicron), RuPhos solution (0.02 M in anhydrous 1,4-dioxane/EtOAc; 75 uL, 1.5 mumo), RuPhos-Pd 2nd generation catalyst (0,02 M in anhydrous 1,4-dioxane, 75 mu., 1 ,5 muetaiotaomicron) and sodium fert-butoxide (2 M in THF; 150 mu^, 300 muthetaIota). The resulting mixture was heated at 100 C overnight. The reaction mixture was cooled to RT and used directly in Step 2 without further workup or i solation.
Statistics shows that 5,6,7,8-Tetrahydroimidazo[1,2-a]pyrazine is playing an increasingly important role. we look forward to future research findings about 91476-80-1.
Reference:
Patent; FORMA THERAPEUTICS, INC.; GUERIN, David Joseph; BAIR, Kenneth W.; CARAVELLA, Justin A.; IOANNIDIS, Stephanos; LANCIA JR., David R.; LI, Hongbin; MISCHKE, Steven; NG, Pui Yee; RICHARD, David; SCHILLER, Shawn E. R.; SHELEKHIN, Tatiana; WANG, Zhongguo; (365 pag.)WO2017/139778; (2017); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem