Related Products of 16298-03-6, The chemical industry reduces the impact on the environment during synthesis 16298-03-6, name is Methyl 2-aminopyrazine-3-carboxylate, I believe this compound will play a more active role in future production and life.
A solution of methyl 3-aminopyrazine-2-carboxylate (3.0 g, 19.6 mmol) and BS (3.5 g, 23.5 mol) in MeCN (70 mL) was stirred at 70C for 5 h. Then the mixture was concentrated and extracted with EtOAc. The organic layer was washed with a2S03 (a.q.) and brine, dried over Na2S04 and concentrated in vacuo. The crude product of methyl 3-amino-6- bromopyrazine-2-carboxylate (3.0 g, yield: 92%) was used for next step without further purification. -NMR (CDC13, 400 MHz) delta 8.18 (s, 1H), 6.54-6.93 (m, 2H), 3.86 (s, 3H). MS (M+H)+: 232 / 234.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-aminopyrazine-3-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; DAI, Xing; LIU, Hong; PALANI, Anandan; HE, Shuwen; NARGUND, Ravi; XIAO, Dong; ZORN, Nicolas; DANG, Qun; MCCOMAS, Casey, C.; PENG, Xuanjia; LI, Peng; SOLL, Richard; WO2014/209727; (2014); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem