Reference of 110223-15-9, A common heterocyclic compound, 110223-15-9, name is 2-Amino-3-benzyloxypyrazine, molecular formula is C11H11N3O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
2-Bromo-3-oxo-butyric acid ethyl ester (15.6 g, 74.6 mmol) was added to a solution of 2-amino-3-benzyloxypyrazine (Compound m in Scheme 1, 5 g, 24.9 mmol) in ethanol (20 mL). The reaction mixture was refluxed for 5 h. The reaction mixture was allowed to cool to r. t. and an off- white coloured solid precipitated out. The solid was collected and washed with ice-cold ethanol to give a white solid (1.08 g, 66%). 1H-NMR (DMSO-d6) No. 11.6 (br s, 1H), 7.97 (d, J5.7 Hz, 1H), 7.00 (t, J 5. 8-Hz, 1H), 4.35 (q, J 7.1 Hz, 2H), 2.52 (s, 3H), 1.34 (t, J 7.1 Hz, 3H); MS (ESI) 222.0 ([M+H])
The synthetic route of 110223-15-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; CARDIOME PHARMA CORPORATION; WO2005/34837; (2005); A2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem