Application of 74290-65-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 74290-65-6 as follows.
To 3-bromo-5-methylpyrazin-2-amine (850 mg,4.52 mmol) was added ethoxycarbonyl isothiocyanate (0.51ml., 4.52 mmol) followed by toluene (1 mL). The mixturewas placed in a preheated 100 C. oil bath, and within aminute, all the solids had dissolved. After 15 min, all hadseized to a solid mass. After an additional 15 minutes, methanol(-5 mL) was added and the mixture refluxed to digest thesolids. The mixture was cooled to rt after 5 minutes and thesolids collected by filtration, washing with methanol to giveethyl 6-methylthiazolo[5,4-b]pyrazin-2-ylcarbamate (680mg, 2.85 mmol, 63.1% yield).
According to the analysis of related databases, 74290-65-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, JAMES H; MCDONALD, IVAR M; KING, DALTON; OLSON, RICHARD E; WANG, NENGHUI; IWUAGWU, CHRISTIANA I; ZUSI, F.CHRISTOPHER; MACOR, JOHN E; (330 pag.)JP5714745; (2015); B2;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem