Application of 55557-52-3,Some common heterocyclic compound, 55557-52-3, name is 3-Chloropyrazine-2-carbonitrile, molecular formula is C5H2ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
At room temperature,(3-(Aminomethyl)cyclobutyl)methyl benzoate (0.3 g, 5 mmol)And triethylamine (0.2 mL, 12 mmol)Add to 3-chloropyrazine-2-carbonitrile (0.5 g, 6 mmol) in THF (10 mL)The reaction solution was reacted at 25 C for two hours.After the reaction is completed,Concentrated under reduced pressure,The residue was purified by silica gel column chromatography (eluent: EtOAc (V/V) = 5/1)The title compound (0.32 g, 54%)
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 3-Chloropyrazine-2-carbonitrile, its application will become more common.
Reference:
Patent; Guangdong Dongyangguang Pharmaceutical Co., Ltd.; Ren Qingyun; Liu Xinchang; Tang Changhua; Zhang Jiancun; Zhang Yingjun; (30 pag.)CN104402833; (2016); B;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem