Synthetic Route of 14508-49-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 14508-49-7, name is 2-Chloropyrazine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below.
General procedure: 2-Aminoethanethiol hydrochloride (1.1-1.2 equiv) was suspended in dry HMPA (1-4 mL). NaH (dry, 95%) (2.4-2.6 equiv) was added portion-wise over 10-20 min while the reaction mixture was cooled in an ice-cold water bath under a nitrogen atmosphere. The mixture was stirred for 10 min at ambient temperature before portion-wise addition of the desired halogenated heterocycle (1.22-17.5 mmol, 1 equiv) over 10 min. The reaction mixture was stirred at ambient temperature for 2 h-2 days. Water was added slowly to quench the reaction then the aqueous layer was extracted with CH2Cl2, and the combined organic extract dried (MgSO4), filtered and solvent removed in vacuo to give the crude product. TLC on silica using CH2Cl2/MeOH/NH3 in MeOH, 9:0.8:0.2 showed the products with Rf values in the range 0.15-0.20.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Chloropyrazine, other downstream synthetic routes, hurry up and to see.
Reference:
Article; Mountford, Simon J.; Campi, Eva M.; Robinson, Andrea J.; Hearn, Milton T.W.; Tetrahedron; vol. 67; 2; (2011); p. 471 – 485;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem