Adding a certain compound to certain chemical reactions, such as: 36070-75-4, name is 5-Chloropyrazine-2-carbonitrile, belongs to pyrazines compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 36070-75-4, Application In Synthesis of 5-Chloropyrazine-2-carbonitrile
To a mixture of 5-chloropyrazine-2-carbonitnle (140mg, l.Olmmol) and [(3R,45)-4- (2,5-difluorophenyl)pyrrolidin-3-yl]carbamic acid rerf-butyl ester (Preparation 48, 300mg, l.Olmmol) in DMSO (ImL) was added DBU (150muL, l.Olmmol). The mixture was bubbled with argon for 5 min and then heated to 700C for 3 h. After cooling to r.t. the crude reaction mixture was partitioned between EtOAc (20OmL) and water (75mL), then the organic phase was separated, washed with brine, dried (MgSO.4), and the solvent removed in vacuo Purification by column chromatography (IH:EtOAc, 60:40) afforded the title compound: RT = 3.93 mm; m/z (ES+) = 402 1 [M + H]+.
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Reference:
Patent; PROSIDION LIMITED; BARBA, Oscar; DAVIS, Susan, Helen; FYFE, Matthew, Colin, Thor; JEEVARATNAM, Revathy, Perpetua; SCHOFIELD, Karen, Lesley; STAROSKE, Thomas; STEWART, Alan, John, William; SWAIN, Simon, Andrew; WITHALL, David, Matthew; WO2010/103335; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem