Application of 54608-52-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54608-52-5, name is 2-Hydrazinopyrazine, This compound has unique chemical properties. The synthetic route is as follows.
To 2-hydrazinopyrazine (2 g, 18.16 mmol) was added isonicotinic acid (pyridine-4- carboxylic acid, 4.47 g, 36.3 mmol, commercially available e.g. from Sigma-Aldrich or Allichem LLC) followed by polyphosphoric acid (50 mL), and the reaction was stirred at 155 0C for 18 hours. The hot solution was added to ice and neutralised by addition of ammonia 0.88. The aqueous solution was then extracted with ethyl acetate (3 extractions), washed with brine, and dried. The yellow solid thus obtained was treated with Dichloromethane, and any remaining solid material was filtered off and put to one side. The filtrate was evaporated and the residue was purified by chromatography using 0-10% of methanol in Dichloromethane as eluent. The fractions containing the product were evaporated to give ~260mg of yellow solid which was combined with the material set aside earlier to give 0.538 g of 3-(4- pyridinyl)[1 ,2,4]triazolo[4,3-a]pyrazine. LCMS: [M+H]+ = 198 retention time = 0.35 minutes (2 minute method)
The chemical industry reduces the impact on the environment during synthesis 2-Hydrazinopyrazine. I believe this compound will play a more active role in future production and life.
Reference:
Patent; GLAXO GROUP LIMITED; DEAN, David Kenneth; MUNOZ-MURIEDAS, Jorge; SIME, Mairi; STEADMAN, Jon Graham Anthony; THEWLIS, Rachel Elizabeth Anne; TRANI, Giancarlo; WALTER, Daryl Simon; WO2010/125102; (2010); A1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem