Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41110-29-6, name is Methyl 3-methylpyrazine-2-carboxylate, A new synthetic method of this compound is introduced below., HPLC of Formula: C7H8N2O2
a) 3-Methyl-4-oxy-pyrazine-2-carboxylic acid methyl ester To a solution of 2.0 g (13.14 mmol) 3-methyl-pyrazine-2-carboxylic acid methyl ester in 40 ml CHCl3 was added 3.24 g (13.14 mmol) meta-chlorperoxybenzoic acid and the resulting mixture was heated to reflux for 1.5 h. The reaction mixture was basified with saturated aqueous NaHCO3 and extraced with CHCl3, the combined organic layers were dried with Na2SO4 and evaporated. The residue was purified by chromatography on silica gel (DCM to DCM/MeOH 9:1) to provide the title compound as colorless solid. HPLC: RtH11=0.40 min; ESIMS [M+H]+=169; 1H NMR (600 MHz, DMSO-d6): 8.56 (d, 1H), 8.48 (d, 1H), 3.33 (s, 3H).
The synthetic route of 41110-29-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Novartis AG; US8338413; (2012); B1;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem