15707-23-0, name is 2-Ethyl-3-methylpyrazine, belongs to pyrazines compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 2-Ethyl-3-methylpyrazine
In an air atmosphere, a nitrogen-containing heterocyclic compound 2e (13.2 mg, 0.1 mmol),Pentamethylcyclopentadienyl iridium (III) chloride dimer (2.0mg), Bistrifluoromethanesulfonimide silver salt (5.8mg), Lithium carbonate (14.8mg) and silver acetate (33.4mg),Use a syringe to inject a 1,2-dichloroethane solution (1.0 mL) containing the alkyne compound 3c (85.6 mg, 0.2 mmol) into the reactor and place the reaction at 120 C for 24 hours.The end of the reaction was determined by thin layer chromatography,The reaction solution was filtered through diatomaceous earth, and then concentrated by spinning with 400 mesh silica gel to prepare a dry powder.The reaction product was separated by column chromatography, 5 g of 400 mesh silica gel,The developing agent is a petroleum ether and ethyl acetate with a volume ratio of 100: 1 to 20: 1 to obtain an alkynyl-containing nitrogen-containing heterocyclic derivative 2-methyl-3-(4-(triisopropylsilyl)-3-butyn-1-yl)pyrazine (1e), 22.0 mg, purity 95%, yield 73%
The synthetic route of 15707-23-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Guangdong University of Technology; Li Xianwei; Rao Jianxing; (22 pag.)CN110256480; (2019); A;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem