In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5049-61-6, name is Pyrazin-2-amine belongs to pyrazines compound, it is a common compound, a new synthetic route is introduced below. COA of Formula: C4H5N3
Pyrazin-2-amine (2.85 g,30 mmol, 1 eq.) was dissolved in CH2Cl2 (150 mL) and cooled in icewaterbath. N-bromosuccinimide (NBS, 5.4 g, 30 mmol, 1 eq.) wasadded portionwise and stirred for 3 h at the same temperature. Themixture was filtered through a Celite, and the filtrate was washed withsaturated aqueous NaHCO3 solution (30 mL×3) and brine, dried overanhydrous Na2SO4 and concentrated under reduced pressure to obtain alight yellow solid 11a (2.7 g, 52%).1H NMR (300 MHz, DMSO-d6): delta8.01 (s, 1H), 7.66 (s, 1H), 6.62 (s, 2H). Compound 12a was synthesizedfrom 11a following the above diazotization and hydrolysis procedure.Yellow solid, yield: 57%. 1H NMR (300 MHz, DMSO-d6): delta 12.21 (br,1H), 8.07 (s, 1H), 7.90 (s, 1H). ESI–MS m/z: 173.0 [M – 1].
The synthetic route of 5049-61-6 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Guo, Shuang; Xu, Mingshuo; Guo, Qi; Zhu, Fuqiang; Jiang, Xiangrui; Xie, Yuanchao; Shen, Jingshan; Bioorganic and Medicinal Chemistry; vol. 27; 5; (2019); p. 748 – 759;,
Pyrazine – Wikipedia,
Pyrazine | C4H4N2 – PubChem